Srijit Ghosh

Biography

Srijit Ghosh is investigating the molecular mechanisms by which M2 muscarinic receptors (M2R) contribute to the pathogenesis of respiratory diseases such as asthma and COPD. This work focuses on identifying novel therapeutic targets to control airway smooth muscle (ASM) contractions. He has shown that M2R-mediated potentiation of cholinergic nerve-induced ASM contractions depends on TMEM16A channel activation and Ca²⁺ influx via L-type Ca²⁺ channels (LTCC), modulated by suppression of SERCA-mediated Ca²⁺ buffering. 

Additionally, using isometric tension recording and patch-clamp electrophysiology, he has explored the roles of specific Kv7 channel isoforms in M2R-driven ASM responses. These findings indicate that postjunctional M2R activation inhibits Kv7 channels, resulting in LTCC activation and enhanced ASM contraction, which highlights Kv7 as a promising target for future bronchodilator therapies in asthma and COPD.